Health care system as well as environment worldwide are facing several challenges. Aging of the population, chronic disease, environment pollution request a novel generation of diagnostics platforms. While conventional labs and their clinical analysis instruments are quite important given their sensitivity, information capability they still suffer from issues such as their high costs, being time consuming, requesting sophisticated equipment etc. Point of care devices (POC) are a great alternative to face overall urgent needs. The demand to develop innovative, cost effective and sustainable devices and fabrication technologies with interest for health and environment care is increasing day by day. How to design simple plastic/paper-based biosensor architectures including wearables through printing or stamping and tune their analytical performance upon demand? How one can couple nanomaterials with paper/plastics and what is the benefit? Which are the perspectives to link these simple platforms and detection technologies with mobile communication? I will try to give responses to these questions through various interesting examples with extreme interest for clinical and environment emergency applications that include important biomarkers as well as highly toxic compounds in environment. These devices and corresponding technologies are related to ubiquitous fabrication methods that would be quite important for democratizing diagnosis and improving healthcare coverage as well as environment monitoring industry.